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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Brain Behav Immun. 2013 Jun 11;33:102–111. doi: 10.1016/j.bbi.2013.06.001

Figure 4. TNFα-Induced an Increase in the Frequency of mIPSCs from CeA Neurons.

Figure 4

(A) Representative mIPSC recording from a neuron in CeA before (control) and during (TNFα) application of TNFα (60 ng/ml) in the presence of 1 μM TTX, 10 μM CNQX and 50 μM AP-5. The bottom current trace shows that 20 μM bicuculline completely blocked these miniature currents, indicating that they were GABAergic. (B) TNFα concentration dependently [r (38) = 0.51; p < 0.05] increased the frequency of mIPSCs [n = 5–10 for individual concentrations, one way ANOVA, F (4, 33) = 3.06, p < 0.05]. (C) TNFα did not to change the amplitude of the mIPSCs [F (4,30) = 0.44; p > 0.05; n = 5–10].