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Chronic Alcohol ingestion during exposure to CDPM increases active TGF-β levels in the lung. (A) Total TGF-β in whole lung tissue homogenates. (B) Tgf-β gene expression in BAL-isolated AMs. (C) Percentage of LAP+ AMs in whole lung. Significance (p<0.05, Two-way ANOVA, Bonferroni post-tests) indicated above sample column by the letters of the reference control group of the comparison. Control+Air (ca), Alcohol+Air (aa), Control+DCB-230 (cd), Alcohol+DCB-230 (ad).
