Figure 6.
CDPM exposure in chronic alcohol fed mice causes loss of alveolar integrity. (A) Representative histological sections of mouse lungs stained by H&E. (B) Alveolar space fraction as determined from total image area minus interstitial fraction. (C) Mean linear intercept measured across the alveoli (3 measurements taken from 6 random images of each replicate). Significance (p<0.05, Two-way ANOVA, Bonferroni post-tests) indicated above sample column by the letters of the reference control group of the comparison. Control+Air (ca), Alcohol+Air (aa), Control+DCB-230 (cd), Alcohol+DCB-230 (ad). Scale bar = 100μm.