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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Neurobiol Dis. 2013 Jul 15;59:52–62. doi: 10.1016/j.nbd.2013.07.002

FIGURE 6. ADOLESCENT INTERMITTENT ETHANOL (AIE) TREATMENT PERSISTENTLY INCREASED EXPRESSION OF TOLL-LIKE RECEPTOR 4 (TLR4) IN THE ADOLESCENT (P56) AND ADULT (P80) ORBITOFRONTAL CORTEX.

FIGURE 6

(A) Profile counts (Cells/mm2) revealed that AIE exposure increased TLR4+IR cells by 32% in the adolescent and 141% in the young adult orbitofrontal cortex (OFC), relative to CONs. Note: There is a maturational reduction of TLR4+IR in the CON OFC from adolescence to young adulthood. ** indicates p<0.01, relative to CON rats. Scale bar = 50 μm. (B) Representative photomicrographs of TLR4+IR in OFC of adolescent (P56) and young adult (P80) CON- and AIE-treated rats. Black arrowheads indicate TLR4+IR cells. Data are presented as mean ± SEM. ** indicates p<0.01, relative to CON rats. Scale bar = 50 μm.