Table 3.
Best Cytogenetic Response to Treatment With Omacetaxine
| n | Major Cytogenetic Response,a n (%) | Other Cytogenetic Response, n (%) | Total Cytogenetic Response, n (%) | ||||
|---|---|---|---|---|---|---|---|
| Complete | Partial | Total MCyR | Minor | Minimal | |||
| All patients | 81b | 8 (10) | 8 (10) | 16 (20)c | 4 (5) | 8 (10) | 28 (35) |
| Response by number of previous TKIs | |||||||
| 2 Previous TKIs | 45 | 6 (13) | 6 (13) | 12 (27) | 2 (4) | 5 (11) | 19 (42) |
| 3 Previous TKIs | 36 | 2 (6) | 2 (6) | 4 (11) | 2 (6) | 3 (8) | 9 (25) |
| Response by previous resistance to or intolerance of TKIs | |||||||
| Resistance to ≥ 2 TKIs | 69 | 7 (10) | 6 (9) | 13 (19) | 3 (4) | 7 (10) | 23 (33) |
| Intolerance of ≥ 2 TKIs | 7 | 0 | 2 (29) | 2 (29) | 1 (14) | 1 (14) | 4 (57) |
| Resistance to 1 TKI and intolerance of 1 TKI | 5 | 1 (20) | 0 | 1 (20) | 0 | 0 | 1 (20) |
Abbreviations: MCyR = major cytogenetic response; TKI = tyrosine kinase inhibitor.
a
Includes confirmed and unconfirmed responses.
b
Twenty-one patients (26%) were not evaluable for response.
c
One-sided 95% lower confidence limit = 12.8%.