Table 1.
In utero treatment and PET measures of [18F]FECNT binding in striatal and midbrain regions.
| [18F]FECNT BPND |
In Utero Maternal Treatment, Mean (sd)
|
Marginal Means (se) | Main Effect of Stress
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Control | Alcohol | Stress | Alcohol + Stress | Control & Alcohol | Stress & Alcohol+Stress | difference | F | p | |
| Striatum | 7.22(1.64) | 6.98(0.86) | 7.91(0.87) | 8.38(1.33) | 7.10(0.27) | 8.15(0.31) | +15% | 6.43 | 0.016* |
| Putamen | 8.10(1.96) | 7.84(1.11) | 8.93(1.22) | 9.71(1.59) | 7.97(0.33) | 9.32(0.39) | +17% | 7.01 | 0.012* |
| Caudate | 6.40(1.40) | 6.16(0.77) | 6.98(0.77) | 7.10(1.13) | 6.28(0.23) | 7.04(0.27) | +12% | 4.49 | 0.041* |
| Head | 7.44(1.61) | 7.11(0.84) | 8.16(0.98) | 8.26(1.25) | 7.28(0.26) | 8.21(0.31) | +13% | 5.23 | 0.028* |
| Body | 4.54(0.93) | 4.59(1.07) | 4.93(1.26) | 5.06(1.39) | 4.56(0.24) | 5.00(0.29) | +10% | 1.33 | 0.257 |
| Tail | 3.14(0.93) | 3.11(0.39) | 3.18(0.41) | 3.44(0.71) | 3.12(0.14) | 3.31(0.17) | +6% | 0.71 | 0.406 |
| Acb | 5.14(0.92) | 5.31(0.73) | 5.59(0.72) | 5.80(0.84) | 5.23(0.17) | 5.69(0.20) | +9% | 2.99 | 0.093 |
| SN/VTA | 1.20(0.20) | 1.25(0.11) | 1.24(0.10) | 1.29(0.20) | 1.22(0.03) | 1.26(0.04) | +3% | 0.51 | 0.480 |
| Subject Characteristics | |||||||||
| F:M | 9:3 | 7:3 | 2:6 | 3:5 | |||||
| Age (yr) | 14.1(0.6) | 13.9(0.8) | 13.7(1.2) | 13.1(1.2) | 14.00(0.20) | 13.39(0.24) | −4% | 3.72 | 0.062 |
| Weight (kg) | 9.7(1.9) | 8.7(2.1) | 10.1(1.0) | 9.9(1.5) | 9.23(0.37) | 10.01(0.44) | +9% | 1.87 | 0.180 |
| Radiotracer Parameters | |||||||||
| ID (MBq) | 189(13) | 188(7) | 185(15) | 189(9) | 188.3(2.4) | 186.8(2.9) | −1% | 0.15 | 0.700 |
| ID/BW (kBq/g) | 20.1(3.8) | 22.7(6.5) | 18.5(3.2) | 19.6(3.5) | 21.4(1.0) | 19.0(1.1) | −11% | 2.54 | 0.121 |
| SA (MBq/nmol) | 29(24) | 34(19) | 28(18) | 54(25) | 31.3(4.6) | 41.0(5.4) | +31% | 1.82 | 0.186 |
| IM/BW (pmol/g) | 1.23(1.03) | 0.92(0.54) | 0.89(0.48) | 0.53(0.46) | 1.07(0.15) | 0.71(0.18) | −34% | 2.37 | 0.133 |
| Aref (g/mL) | 0.94(0.20) | 1.04(0.20) | 0.97(0.14) | 0.96(0.14) | 0.99(0.04) | 0.96(0.04) | −3% | 0.22 | 0.642 |
| Mref (pmol/mL) | 1.14(1.00) | 0.98(0.67) | 0.85(0.42) | 0.47(0.33) | 1.06(0.15) | 0.66(0.18) | −38% | 2.94 | 0.095 |
Acb = nucleus accumbens, SN/VTA = substantia nigra/ventral tegmental area; ID = injected dose of [18F]FECNT; ID/BW = injected dose per body weight; SA = specific activity of radiotracer at injection; IM/BW = injected mass per body weight; Aref = reference region radioactivity/(injected dose/body weight) 90–150 min after injection; Mref = reference region radioactivity/SA = reference region tracer mass concentration 90–150 min after injection; main effect of stress: difference = (stress/no stress) − 1, 2 (Stress) × 2 (Alcohol) ANOVA, F(1, 34), p: 2-tailed,
*
p<0.05.