Table 2.

Pre Quit Phase Cigarette Smoking and Other Behavioral and Subjective Effects

	Pre-Quit Phase		Linear Regression Models Testing Medication Effect
	Placebo (n=154)	Naltrexone (n=161)	Mean Difference (95% CI)	p values
				Unadjusted: Medication Effect Only	Adjusted for Demographic Characteristics	Adjusted for Demographics and Nausea	Adjusted for Demographics, Nausea and Baseline
Primary Outcomea
Cigarettes per day	−2.93 (4.54)	−4.21 (4.45)	1.28 (0.28 to 2.27)	0.01	0.02	<0.05	0.02
Secondary Behavioral Outcomes a
Alcoholic drinks per drinking day	−1.98 (2.98)	−1.94 (2.77)	0.95 (0.21 to 1.70)	0.01	0.02	0.01	0.04
Caffeinated drinks per day	−1.22 (2.84)	−1.35 (2.21)	0.13 (−0.46 to 0.71)	0.7	0.83	0.95	0.9
Secondary Subjective Effects b:
Smoking Urge	2.58 (0.64)	2.32 (0.65)	0.25 (0.11 to 0.40)	<0.01	<0.01	0.01	0.02
Cigarette Pleasure	2.40 (0.62)	2.22 (0.63)	0.18 (0.04 to 0.32)	0.01	0.01	0.06	0.07
Cigarette Taste	2.32 (0.61)	2.12 (0.63)	0.19 (0.05 to 0.33)	0.01	0.01	0.04	0.08
Appetite ratings	2.93 (0.58)	2.72 (0.66)	0.20 (0.07 to 0.34)	<0.01	<0.01	0.09	0.42
Food Pleasure	2.88 (0.48)	2.72 (0.58)	0.17 (0.05 to 0.28)	0.01	0.01	0.08	0.30
Sweet food consumption	2.83 (0.65)	2.64 (0.69)	0.19 (0.05 to 0.34)	0.01	0.01	0.08	0.11

Note: Data are Mean change score (SD), or Mean score (SD).

^aBehavioral outcomes (cigarettes, alcoholic and caffeinated drinks) are expressed as change scores during pre-quit days 4–6 from baseline (2 weeks prior to enrollment).

^bSubjective effects were rating average on the 5-point scale and did not have a pre-treatment baseline.