Table 2. Haplotypes within “LD Block 2” significantly associated with ad in primary population.
Haplotype# | Allele | Haplotype score | Simulated P value for individual haplotype* | Frequency | Odds ratio OR (95 % CI) | Global P value | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
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rs12270070 | rs1176744 | rs2276305 | rsl7116138 | rs2276307 | rs3782025 | rsl672717 | AD (N = 500) | Controls (N = 280) | |||||
1 | G | A | A | A | A | −2.693 | 0.007 | 0.230 | 0.294 | 0.785 (0.598, 1.031) | 0.0004 | ||
2 | G | A | G | G | A | A | A | −2.365 | 0.014 | 0.223 | 0.279 | 0.811 (0.617, 1.066) | 0.0110 |
3 | G | A | A | G | A | A | A | Sample too small for statistical analysis | 0.006 | 0.016 | n/a |
Rare allele is indicated in underlined italic font; blank cells indicate loci not included in haplotype analysis. Negative haplotype scores indicate a protective effect and positive haplotype scores a risk effect for AD
P value for allelic associations with AD in individual SNP analysis using logistic regression test