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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Hum Genet. 2013 Jun 12;132(10):1165–1176. doi: 10.1007/s00439-013-1319-y

Table 2. Haplotypes within “LD Block 2” significantly associated with ad in primary population.

Haplotype# Allele Haplotype score Simulated P value for individual haplotype* Frequency Odds ratio OR (95 % CI) Global P value


rs12270070 rs1176744 rs2276305 rsl7116138 rs2276307 rs3782025 rsl672717 AD (N = 500) Controls (N = 280)
1 G A A A A −2.693 0.007 0.230 0.294 0.785 (0.598, 1.031) 0.0004
2 G A G G A A A −2.365 0.014 0.223 0.279 0.811 (0.617, 1.066) 0.0110
3 G A A G A A A Sample too small for statistical analysis 0.006 0.016 n/a

Rare allele is indicated in underlined italic font; blank cells indicate loci not included in haplotype analysis. Negative haplotype scores indicate a protective effect and positive haplotype scores a risk effect for AD

*

P value for allelic associations with AD in individual SNP analysis using logistic regression test

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