. Author manuscript; available in PMC: 2014 Oct 1.

Published in final edited form as: Hum Genet. 2013 Jun 12;132(10):1165–1176. doi: 10.1007/s00439-013-1319-y

Table 4. Significant individual genetic associations and gene 9 gene interactions for AD in replication population.

SNP/genotype combination	Frequency (total population N = 6,699)	# of families	Comparison	Z score/Chi square*	P value
HTR3A: rs33940208	T/C: 0.012/0.988	13	T vs. C	3.316*	0.0686
	TT/TC/CC: 0.0001/0.016/0.973		TT/TC vs. CC	−2.014	0.0440
HTR3B: rs2276305	A/G: 0.011/0.989	17	A vs. G	7.224*	0.0071
	AA/AG/GG: 0.0004/0.018/0.978		AA/AG vs. GG	−2.555	0.0106
SLC6A4: 5HTTLPR:LL/LS, rs1042173:TT/TG HTR3B: rs1176744:AC, rs3782025:AG	12.95	181	Genotype combination vs. “ All other”	4.384	0.00001
SLC6A4: 5HTTLPR:LL/LS HTR3A: rs10160548:GT/TT HTR3B: rs1176744:AC, rs3782025:AG	11.72	143	Genotype combination vs. “ All other”	3.155	0.0016
SLC6A4: 5HTTLPR:LL/LS, rs1042173:TT/TG HTR3A: rs10160548:GT/TT HTR3B: rs1176744:AC, rs3782025:AG	9.435	118	Genotype combination vs. “All other”	3.389	0.0007

“All other” refers to any genotype combination other than the one specified