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Induced neurons from DS patients, but not controls, often display spontaneous bursting behavior/repetitive firing at resting membrane potential.
| iPSCs | Control (%) | DS patient (%) |
|---|---|---|
| Pyramidal-shaped | 0 (0/7) | 68 (19/28) |
| Bipolar-shaped | 4 (1/27) | 49 (18/37) |
| Overall | 3 (1/34) | 57 (37/65) |
