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Grade ≥3 adverse events occurring in ≥2 patients, by MedDRA preferred term
| Barasertib dose + LDAC 400 mg | ||||
|---|---|---|---|---|
| Adverse event, n (%) | 800 mg (n=6) |
1000 mg (n=13) |
1200 mg (n=3) |
Total (n=22) |
| Any grade ≥3 AE* | 6 | 12 | 3 | 21 (96) |
| Febrile neutropenia | 4 | 9 | 0 | 13 (59) |
| Neutropenia | 1 | 2 | 1 | 4 (18) |
| Stomatitis | 0 | 2 | 2 | 4 (18) |
| Pneumonia | 0 | 3 | 0 | 3 (14) |
| Anemia | 2 | 0 | 0 | 2 (9) |
| Diarrhea | 1 | 1 | 0 | 2 (9) |
| Thrombocytopenia | 1 | 1 | 0 | 2 (9) |
All events are grade 3 except for thrombocytopenia (both grade 4)
