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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Neurobiol Dis. 2013 Jul 2;59:1–17. doi: 10.1016/j.nbd.2013.06.013

Figure 11. ELS mediates loss of S6K from FMRP-PP2A–S6K complex and a decrease in synaptosomal STEP at P60.

Figure 11

A, FMRP-IPs from CA1 hippocampal lysates probed for PP2AC (ELS: 101.77 ± 7.93%, n = 7; control: 100 ± 5.17%, n = 8, P = NS, Student’s t-test) and S6K (ELS: 65.52 ± 11.63%, n = 7; control: 100 ± 10.22%, n = 8, P < 0.05, Student’s t-test) show unchanged interaction of FMRP and PP2AC but reduced interaction of FMRP and S6K associated with ELS. B, STEP S2 (cytosolic) fraction was not changed (ELS: 123.40 ± 17.70%, n = 7, control: 100 ± 15.51%, n = 7, P = NS, Student’s t-tests). STEP was increased in the synaptosomal compartment (P2 fraction, ELS: 218.95 ± 51.05%, n = 7; control: 100 ± 21.16%, n = 8, P < 0.05, Student’s t-test). Solid bars ELS, open bars control.