Figure 1.
Percent change in monotherapy antiepileptic drug dosage each trimester of pregnancy.
aOther AED monotherapy included topiramate (n=3), oxcarbazepine (n=2), valproate (n=1), zonisamide (n=1), and ethosuximide (n=1). Phenytoin was not included because no non-pregnant baseline dose was available. Dosage data for all individual AEDs and for polytherapy regimens is provided in Table e-2. LTG = lamotrigine; LEV = levetiracetam; CBZ = carbamazepine.