Skip to main content
. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Neurobiol Dis. 2013 Jul 13;59:26–37. doi: 10.1016/j.nbd.2013.07.001

Figure 6. Rescue of axon transport by p38 MAPK inhibition is not due to changes in CTB uptake.

Figure 6

A) Confocal micrographs through the nerve fiber and ganglion cell layers of whole-mounted retina from vehicle and drug cohorts showing CTB-labeled RGCs and their axons. As in Figure 3, retina from microbead-injected eyes demonstrate increased phosphorylated p38 MAPK (p-p38) in both cohorts; arrows indicate particular examples of CTB-labeled RGCs with p-p38 localizing in the nucleus. Scale = 20 μm. B) Quantification indicates similar numbers of CTB-labeled RGCs between cohorts, for both saline and microbead retina. Thus, differences in anterograde transport to the SC as shown in Figure 4 are not due to differences in CTB uptake by RGCs. n ≥ 3 sets of retina per cohort.