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rsFC strength in a PCC-mPFC circuit was increased by nicotine in abstinent smokers. A whole-brain PATCH main effect identified brain regions whose rsFC with a PCC seed (S, green: center coordinate obtained from the insula-centric analysis in Fig. 2B; x = 2, y = −54, x = 26; 29 voxels) was modulated by nicotine. Across all PILL-levels, nicotine increased rsFC between the PCC and mPFC (1: x = 6, y = 60, x = 2; 56 voxels). No indications of a varenicline effect were observed.
