Precursors of varying charge state were interrogated by AI-ETD with laser powers at 30, 40, and 50 W. The probability of identification for 50 m/z bins for +3 precursors demonstrates the need for higher laser powers at higher m/z (A). Analysis identical to (A) was performed for charge states 2, 3, 4, 5, and >5 and plots were used to construct decision tree logic for AI-ETD laser power settings depending on precursor z and m/z (B). Here, the laser power setting that produced the highest probability of PSM was chosen as the value in the decision tree.