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. 2013 Sep 18;33(38):15306–15317. doi: 10.1523/JNEUROSCI.0837-13.2013

Figure 6.

Figure 6.

Treatment with a leptin receptor antagonist fails to alter NPY or CART mRNA in 20 week DIO mice. A, NPY (top) and CART (bottom) mRNA expression in the DMH of DIO mice (arrows) not significantly altered by intracerebroventricular treatment of a leptin receptor antagonist (3 doses of 2.5 μg over 36 h); n = 6 animals per group. B, Intracerebroventricular treatment with a leptin receptor antagonist (2.5 μg) blocked the ability of peripherally administered leptin (2 μg/g body weight, i.p.) to induce pSTAT3-ir in the DMH of DIO mice. C, Quantification of pSTAT-ir in the DMH. The asterisks indicate a significant induction of pSTAT3-ir, as determined by one way ANOVA; ***p < 0.0001; n = 3–5 animals per group.