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Levels of phosphorylated tau (pTau) at Ser396 in the cortex (a) and hippocampus (b) of SAMP8 and SAMP8 Rsv groups. Cortex and hippocampal levels of CDK5 (c, d), P25/P35 ratio (e, f). Bars represent mean±SEM and values are adjusted to 100 % for levels of SAMP8 control mice. Student’s paired t test; *P < 0.05; **P < 0.01 vs. SAMP8. Cortex (Cx), hippocampus (Hp)
