Table 4.

Plasma total testosterone levels, CRP, and adiponectin of rats from all experimental groups

	Baseline	6 months			12 months			18 months
		C	HFD	ER	C	HFD	ER	C	HFD	ER	HF/ER
Total testosterone (ng mL−1)	0.80 ± 0.18	1.43 ± 0.60	0.17 ± 0.09a	0.81 ± 0.29	0.34 ± 0.14	0.25 ± 0.06	0.45 ± 0.13	0.38 ± 0.15	0.17 ± 0.03	0.31 ± 0.09	0.72 ± 0.21
CRP (mg dL−1)	4.5 ± 0.6	5.4 ± 0.9	8.8 ± 1.2	9.6 ± 1.2a	4.2 ± 1.1	6.0 ± 1.7	7.0 ± 1.0	3.6 ± 0.5	8.4 ± 1.0c	7.8 ± 2.1	3.6 ± 1.1d
Adiponectin (μg mL−1)	3.2 ± 0.4	6.0 ± 1.2	2.3 ± 0.3a	10.5 ± 0.7ae	4.8 ± 0.9	4.3 ± 0.6e	7.1 ± 0.6bf	4.3 ± 0.9	3.0 ± 0.3f	7.5 ± 1.0cd	2.8 ± 1.0g

Data are presented as mean ± SEM

C control group, HFD high-fat diet, ER energy-restricted group, HF/ER high-fat diet-fed group of rats that were energy restricted from 12 to 18 months

^aP < 0.05 vs. 6-month C; ^bP < 0.05 vs. 12-month HFD; ^cP < 0.05 vs. 18-month C; ^dP < 0.05 vs. 18-month HFD; ^eP < 0.05 vs. 6-month HFD; ^fP < 0.05 vs. 6-month ER; ^gP < 0.05 vs. 18-month ER