Table 2.
Associations between regional R2* and CWMHV using partial Pearson correlation analysis models
| Brain regions | Log-transformed corrected WMH volume | ||
|---|---|---|---|
| Partial Pearson correlation (model 1, r (P)) | Partial Pearson correlation (model 2, r (P)) | Partial Pearson correlation (model 3, r (P)) | |
| Red nucleus | 0.281 (0.046) | 0.321 (0.025) | 0.302 (0.183) |
| Substantia nigra | 0.148 (0.299) | 0.178 (0.221) | 0.274 (0.229) |
| Globus pallidus | 0.510 (<0.001) | 0.521 (<0.001) | 0.572 (0.033) |
| Putamen | 0.206 (0.146) | 0.209 (0.150) | 0.291 (0.200) |
| Head of caudate | −0.194 (0.172) | −0.229 (0.114) | −0.139 (0.548) |
| Thalamus | 0.065 (0.652) | 0.078 (0.595) | −0.028 (0.903) |
| Frontal white matter | −0.148 (0.301) | −0.146 (0.317) | −0.107 (0.644) |
Model 1 adjusted for age, Model 2 adjusted for age and other sociodemographic variables (sex and years of education), Model 3 adjusted for age, sex, years of education, and vascular risk factors (hypertension, diabetes, hyperlipidemia, serum glucose level, systolic and diastolic blood pressure, total cholesterol, total homocysteine, and high-sensitivity C-reactive protein)