Fig. 3.

Igfals gene inactivation associates with reduced intracortical remodeling and reduced TRAP staining. a Plasma osteocalcin levels (n = 10–16). b Serum TRAP5b levels (n = 8–16). c Fluorescent images of thick sections from WT and ALSKO femora at 104 weeks of age. Arrows indicate bone formation at sites of intracortical porosities. d Quantification of intracortical remodeling; e Bright field images of WT and ALSKO femoral cortical sections from 104-week-old mice stained for TRAP