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. 2013 Sep 18;7:156. doi: 10.3389/fncel.2013.00156

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Copyright © Maheshwari, Nahm and Noebels.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Cortical PV⁺ interneurons in stargazer mutant mice show clear evidence of GluA4 mistrafficking in dendrites. Strong labeling in WT dendrites (arrows) is consistently diminished in stargazer interneurons. A relative decrease in the density of dendritic GluA4 immunoreactivity can be demonstrated by comparison of the dendrite:soma immunostaining ratio in stargazer interneurons compared to WT interneurons (scale = 10 μm). (B) Quantification of mean dendrite:soma ratio of GluA4 staining reveals a significant decrease in mutant PV⁺ interneurons (mean ratio of 0.753 for +/+, n = 15, vs 0.396 for stg/stg, n = 18, *p < 0.001).