FIGURE 6.

Stargazer mutant paradoxical cortical excitability defect is maintained in vitro. (A) The frequency of spontaneous network discharges in WT cortical slices bathed in Mg²⁺-free solution (upper trace) is decreased in 10 μM CPP (lower trace). (B) In contrast, discharge activity in stargazer cortical networks is increased following CPP exposure. (C) Group data reveal mean discharge frequency in WT is significantly decreased by 10 μM CPP (n = 4) and increased in stargazer slices (n = 4), *p < 0.001. (D) No significant difference in mean discharge duration between WT and stargazer mice before or after administration of CPP.