FIGURE 7.

Non-competitive NMDA receptor blockade with MK-801 also provokes paradoxical cortical network hyperexcitability in vitro. (A) In 0 Mg²⁺, discharges in WT cortex show a dose-dependent reduction in duration and frequency with application of MK-801. (B) In contrast, spontaneous 0 Mg²⁺-induced network bursting in stargazer cortical slices accelerates with increasing doses of MK-801. (C) Graphical representation of divergent response to increasing doses of MK-801 in WT and stargazer mice (*p < 0.05, **p < 0.005). In (D), there is a coordinate reduction in discharge duration with no significant difference between groups at each incremental concentration of MK-801.