FIGURE 8.

Paradoxical exacerbation in stargazer cortex requires GABAergic synaptic transmission. (A,B) Spontaneous 0 Mg²⁺-induced network discharges in WT and stargazer cortex (upper traces) are accelerated by combined GABA _A and GABA _B receptor blockade (middle traces); however, in this disinhibited condition, application of 10 μM CPP strongly and equally attenuates network bursting in both genotypes (lower traces). (C) Exacerbation of epileptiform discharges by CPP is not evident in WT or stargazer slices with complete GABAergic blockade (n = 4 per group, *p < 0.05, **p < 0.001).