Table 1. Baseline Characteristics of the Studied Patients in Relation to Virological Response.
| Demographic Features | Non Responder | Relapsers | Responders | P value |
|---|---|---|---|---|
| Gender No. (%) | 0.21 | |||
| Male 190 (72.2%) | 54 (28.4) | 57 (30) | 79 (41.6) | |
| Female 73 (27.8%) | 29 (40) | 19 (26) | 25 (34) | |
| Age, y, Mean ± SD | 44.78 ± 8.1 | 45.27 ± 7.82 | 42.94 ± 8.23 | 0.207 |
| BMIa, Mean ± SD | 28.9 ± 4.47 | 27.94 ± 3.63 | 28.42 ± 4.07 | 0.378 |
| Baseline Laboratory Data | ||||
| Hemoglobin (12-16g/dl), Mean ± SD | 13.93 ± 1.66 | 14.18 ± 1.53 | 14.36 ± 1.56 | 0.4 |
| TLCa(4.000-11.000/mm3), Mean ± SD | 6.01 ± 1.6 | 6.76 ± 2.23 | 6.82 ± 1.79 | 0.76 |
| ANCa, Mean ± SD | 3.1 ±1.09 | 3.82 ±1.97 | 3.55 ±1.35 | 0.12 |
| Platelets (150.000-400.000/mm3), Mean ± SD | 197.7 ± 66.7 | 203.3 ± 64.03 | 231.1 ± 25.3 | 0.015 |
| ALTa(40) IU/L, Mean ± SDb | 56 ± 51 | 52 ± 44 | 52 ± 42 | 0.23 |
| ASTa(40) IU/L, Mean ± SDb | 53 ± 46 | 49 ± 38 | 45 ± 33 | 0.01 |
| Bilirubin (0.3-1.2mg/dl), Mean ± SD | 0.51 ± 0.19 | 0.56 ± 0.27 | 0.56 ± 0.24 | 0.56 |
| ALPa(290) IU/Lb, Mean ± SD | 151 ± 124 | 161 ± 129 | 151 ± 120 | 0.81 |
| Albumin (3.5-5g/dl), Mean ± SD | 4.29 ± 0.42 | 4.15 ± 0.46 | 4.32 ± 0.48 | 0.89 |
| Creatinine (mg/dl), Mean ± SD | 0.87 ± 0.17 | 0.90 ± 0.20 | 0.90 ± 0.30 | 0.214 |
| Glucose (70-130 mg/dl), Mean ± SD | 102.2 ± 28.2 | 102.7 ± 27.7 | 100.4 ± 22.3 | 0.87 |
| TSHa(0.5-4.5 mIU/L), Mean ± SD | 1.69 ± 1.28 | 1.39 ± 0.81 | 1.52 ± 0.94 | 0.34 |
| AFPa(10 ng/dl)b, Mean ± SD | 4 ± 7.4 | 5.1 ± 6.1 | 2.3 ± 2.9 | 0.001 |
| Hepatitis C Virus RNA log (10 IU)b, Mean ± SD | 5.14 ± 1.12 | 5.04 ± 1.14 | 5.02 ± 1.27 | 0.86 |
| Histological Parameters | ||||
| < Fa2 N = 170 (64.4%), No. (%) | 52 (30.5) | 47 (27.6) | 71 (41.9) | 0.45 |
| ≥ F2 N = 93 (35.4%), No. (%) | 31 (33.3) | 29 (31.2) | 33 (35.5) | |
| < Aa2 N = 234 (89.1%), No. (%) | 74 (31.6) | 67 (28.6) | 93 (39.8) | 0.76 |
| ≥ A2 N = 29 (10.9%), No. (%) | 9 (31) | 9 (31) | 11 (38) |
aAbbreviations: BMI, body mass index; TLC, total leucocytic count; ANC, absolute neutrophilic count; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; TSH, Thyroid stimulating hormone; AFP, alpha fetoprotein; F, fibrosis; A, activity
bMedian (IQR) Mann-Whitney u test