Table 1.
Subjects' demographic and clinical information including gender, age, cotinine level, current antipsychotic medication dose, as calculated by chlorpromazine equivalent (CPZ), and Fagerstrom Test for Nicotine Dependence (FTND) scores, a measure of smoking addiction severity.
| Discovery cohort | Replication cohort | |||||||
|---|---|---|---|---|---|---|---|---|
| Whole sample | Low cotinine | High cotinine | p-value | Whole sample | Low cotinine | High cotinine | p-value | |
| Subjects (M/F) | 39 (34/5) | 17 (15/2)* | 17 (14/3)* | 0.6 | 38 (18/20) | 19 (10/9) | 19 (8/11) | 0.5 |
| Cotinine (±sd) | 321.7 ± 143.1 | 208.1 ± 77.4 | 428.4 ± 94.4 | 1.00E-08 | 283.2 ± 102.0 | 194.9 ± 94.1 | 363.6 ± 73.5 | 2.00E-07 |
| Age (±sd) | 37.1 ± 10.6 | 39.1 ± 10.8 | 35.2 ± 10.4 | 0.32 | 31.8 ± 7.6 | 31.6 ± 7.3 | 31.9 ± 8.1 | 0.9 |
| Patients/controls | 19/20 | 7/10* | 10/7* | 0.4 | N/A | N/A | N/A | N/A |
| CPZ (±sd) | 397.4 ± 237.8 | 427.4 ± 263.8 | 379.2 ± 233.6 | 0.7 | N/A | N/A | N/A | N/A |
| FTND (±sd) | 4.6 ± 2.1 | 3.8 ± 2.2 | 5.4 ± 1.7 | 0.005 | 5.9 ± 2.3 | 5.1 ± 1.9 | 6.8 ± 2.3 | 0.02 |
| Pack years (±sd) | 19.8 ± 16.6 | 19.0 ± 15.1 | 21.2 ± 18.4 | 0.7 | 15.2 ± 9.7 | 13.9 ± 7.6 | 16.6 ± 11.6 | 0.4 |
The two cohorts were further subdivided into high and low average cotinine groups. P-values were from two-tailed t-test or χ2 test, to evaluate difference between high and low cotinine subgroups.
*
Average cotinine measurements were available for 34 subjects in the first sample, including 17 patients and 17 controls.