Table II.
Parameters of platelet aggregation (mean ± SD): maximal aggregation Amax (%T) and initial velocity v 0 (%T/min)
| Aggregation inductor | Parameter | Atorvastatin (n = 20) | Simvastatin (n = 18) | Pravastatin (n = 12) | Control (n = 20) | |||
|---|---|---|---|---|---|---|---|---|
| Baseline | 8-Week treatment | Baseline | 8-Week treatment | Baseline | 8-Week treatment | |||
| ADP | Amax [%T] v 0 [%T/min] |
50.6 ±12.8 40.8 ±15.0 |
41.1 ±15.8** 32.9 ±14.7 |
57.2 ±18.0 40.26 ±12.3 |
44.7 ±22.1* 32.4 ±18.9 |
55.8 ±19.5 33.4 ±19.2 |
38.81 ±23.39**
/
+ 24.92 ±13.35* / ++ |
48.6 ±15.4 37.2 ±14.7 |
| Ristocetin | Amax [%T] v 0 [%T/min] |
57.2 ±10.7 39.4 ±13.4 |
54.8 ±20.3 38.9 ±18.5 |
61.2 ±24.8 35.3 ±9.8 |
60.1 ±20.9 39.3 ±18.3 |
65.73 ±27.1 37.9 ±18.4 |
58.83 ±26.0 34.2 ±17.0 |
62.1 ±7.8 41.2 ±13.6 |
| Collagen | Amax [%T] v 0 [%T/min] |
41.5 ±21.2 29.7 ±17.5 |
43.0 ±20.8 33.3 ±19.2 |
41.9 ±20.7 27.1 ±17.5 |
39.8 ±23.5 21.95 ±17.9 |
– – |
– – |
40.7 ±25.0 27.0 ±18.2 |
*
p = 0.05 vs. baseline
**
p < 0.05 vs. baseline
+
p = 0.05 vs. control
++
p < 0.05 vs. control