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. 2013 May 8;1:4. doi: 10.1186/2051-5960-1-4

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Copyright © 2013 Lai et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Case 4 XP-C Neuropathologic changes. A: The cerebellum shows focal loss of Purkinje cells (x100). B-E: Sections of optic nerves and geniculate nuclei reveal degenerative changes, including axonal loss, gliosis, and fibrosis (arrows) in keeping with the patient’s 10 year history of bilateral orbital exenterations (B. H&E x200; C. immunostain for Bielschowsky, x200 D. Masson stain, x200, E. LFB/PAS stain, x200). F. Dorsal root ganglia show severe neuronal loss and accompanying fibrosis (H&E, x200).