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. 2013 Aug 10;3(9):650–657. doi: 10.7150/thno.6668

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 2 — a) Cytotoxicity studies. FL-SiO₂nanoparticles were not toxic to U87MG cells in the tested concentration range (0-100 µg/mL). On the other hand, Dox-FL-SiO₂ nanoparticles showed concentration dependent toxicity against U87MG cells. b) Drug release study with Dox-FL-SiO₂nanoparticles in PBS. c) Cellular uptake studies. After being incubated with U87MG cells for 1 h, we observed good uptake with RGD-FL-SiO₂nanoparticles, but not with NH₂-FL-SiO₂nanoparticles. The fluorescence signals are from the FL-SiO₂ nanoparticles. Scale bar: 50 µm.