Table 2.

Spatial distribution of focal T2*w hypointensities. This table shows the anatomical locations of the individual T2*w hypointensities, i.e. the connected components (six-connected neighborhood) of the T2*w hypointensity masks from the rater. Additionally, it shows how many individual T2*w hypointensities were marked as partly or completely hypointense on T1w MRI. Regions within individual T2*w hypointensities that appeared hypointense on T1w might potentially indicate a change in the underlying tissue composition, such as calcification (Kruer et al., 2012; Valdés Hernández et al., 2012).

Anatomical structure	Total count	Marked as partly hypointense on T1w MRI	Marked as completely hypointense on T1w MRI
Basal ganglia and internal capsule
Caudate	5	0	0
Putamen	26	0	1
Globus pallidus	229	46	5
Internal capsule	58	0	1
Total	318	46	7
Outside the basal ganglia and internal capsule
Choroid plexus	325	4	317
Pineal gland	55	2	52
Substantia nigra	32	0	0
Other structures	137	3	9
Total	549	9	378