Fig. 5.

Piperine and SCT-66 dose-dependently reduce locomotor activity in the OF test. Bars indicate in (A) the total distance travelled, in (B) the time spent in the centre, in (C) the number of entries to the centre and in (D) the distance travelled in the centre as % of the total distance after application of the indicated dose (mg/kg bodyweight) of piperine (black bars), SCT-66 (shaded bars) or control (white bars). Bars always represent means ± S.E.M. from at least 8 different mice. (*) indicates statistically significant differences with p < 0.05, (**) p < 0.01 to control (ANOVA with Bonferroni).