Table 4.

Therapy and prophylaxis for candidiasis^a

Therapy/prophylaxis	Drug	Therapeutic regimen
Acute therapy
First choice	Fluconazole	200 mgb/100 mg 1×/day p.o. for oral candidiasis (topical therapy only in very mild cases) for 5–14 days 1 × 200 (–400) mg p.o. for esophageal candidiasis (twice the dose on the first day in each case) for 10–14 days If Fluconazole not tolerated p.o., it might be given i.v.
Alternatives (in moderate cases)	Amphotericin	Suspension 4 × 1 ml (100 mg) up to 48 h after symptoms resolve
	Nystatin	4 × 1 ml (100,000 I.E.) up to 48 h after symptoms resolve
Alternatives in case of fluconazole intolerance	Itraconazole	400 mg loading days 1-3b/then 100–200 mg 2×/day p.o. (only as suspension due to poor bio-availability of capsules)
	Posaconazole	400 mg 2×/day p.o. (suspension)
	Voriconazole	400 mgb/200 mg 2×/day p.o.
Alternatives for Azole failure	Anidulafungin	200 mgb/100 mg 1×/day i.v.
	Caspofungin	70 mgb/50 mg 1×/day i.v.
	Micafungin	150 mg 1×/day i.v.
Prophylaxis
Primary prophylaxis	Not recommended
Secondary prophylaxis	In individual cases, generally not recommended
	Amphotericin	Suspension 4×1 ml/day p.o. (100 mg)
	Fluconazole	If necessary 50 mg every 48 h or 150 mg 1×/week

^aDaily doses

^bKeep in mind the loading dose on the first day; with itraconazole for at least 3 days