Table 5.

Therapy and prophylaxis of genital Herpes simplex virus infections^a

Therapy/prophylaxis	Drug	Therapeutic regimen
Acute therapy (duration: 7–10 days), daily doses
First choice	Acyclovir	(3–) 5 × 400 mg p.o.
Severe cases		3 × 5–10 mg/kg i.v. 5 × 800 mg p.o.
Alternatives	Valacyclovir	2–3 × 1,000 mg or 3 × 500–1,000 mg (expert opinion)
Therapy for recurrent Herpes simplex infection virus episodes	Acyclovir	3 × 400 mg p.o. for 5–10 days
	Valacyclovir	2 × 1,000 mg for 5–10 days
	Famciclovir	2 × 500 mg for 5–10 days
Long-term prophylaxis (duration: at least 90 days)	Acyclovir	2–3 × 400–800 mg
	Valacyclovir	2 × 500 mg
	Famciclovir	2 × 500 mg

^aDaily doses