Table 9.

Therapy and prophylaxis of cryptococcosis^a

Therapy/prophylaxis	Drug	Therapeutic regimen
Acute therapy
Induction therapy (treat at least 2 weeks before switch/de-escalation)
First choice	Amphotericin B + flucytosine	1 × 0.7 mg/kg/day i.v. or liposomal Amphotericin B (AmBisome®) 1 × 3–4 mg/kg/day i.v. + Ancotil® 4 × 25 mg/kg/day i.v./p.o. or 100 mg/day distributed in four separate doses
De-escalation with good response (at least after 2 weeks)
First choice	Fluconazole	1 × 400 mg p.o. (For at least 8 more weeks)
Alternatives	Itraconazole	2 × 200 mg p.o. (For at least 8 more weeks)
Primary prophylaxis	Not recommended in Germany
Secondary prophylaxis	Fluconazole	200 mg/day p.o.
Discontinuation is possible when CD4 T-cell count is >100 cells /μl and HIV-RNA below detection limit for a period of 6 months

^aDaily doses, unless specified otherwise