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. 2013 Sep 16;202(6):875–886. doi: 10.1083/jcb.201305094

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© 2013 Xu et al.

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Figure 8. — Model for the role Drs2 PS flippase activity plays in generating membrane curvature and negative charge in the cytosolic leaflet that is sensed by the +ALPS motif of Gcs1. PS flip is crucial for the AP-1–dependent trafficking of Chs3 between the TGN and EE, as well as the AP-1–independent transport of Snc1 from the EE to the TGN.