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. 2013 Sep 16;202(6):849–859. doi: 10.1083/jcb.201302131

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© 2013 Choi et al.

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Figure 2. — FAK autophosphorylation is pH dependent in vitro. (A) Time- and pH-dependent increase in pY397 of recombinant FAK containing the FERM domain (F), interdomain linker (L), and kinase domain (K). (B) Time-dependent increase in pY397 with L and K but lacking F is pH independent. (C) Abundance of pY397 relative to pH 7.5. Data are means ± SEM of the indicated constructs from A and B from three independent experiments. (D and E) Time- and pH-dependent increase in pY397 of a GST fusion of F and L induced in trans by F and L and K (D) or by L and K (E).