Table 1.
The first 20 prediction accuracies of the interaction-based and similarity-based methods in identifying the side effects of drugs in the training and test datasets.
| Prediction order | Interaction-based | Similarity-based | Difference | |||
|---|---|---|---|---|---|---|
| Training dataset | Test dataset | Training dataset | Test dataset | Training dataseta | Test datasetb | |
| 1 | 86.30% | 89.16% | 83.64% | 87.95% | 2.66% | 1.20% |
| 2 | 80.45% | 83.13% | 79.12% | 83.13% | 1.33% | 0.00% |
| 3 | 77.13% | 84.34% | 75.00% | 79.52% | 2.13% | 4.82% |
| 4 | 72.61% | 81.93% | 71.41% | 75.90% | 1.20% | 6.02% |
| 5 | 73.40% | 77.11% | 68.22% | 74.70% | 5.19% | 2.41% |
| 6 | 68.75% | 75.90% | 66.89% | 71.08% | 1.86% | 4.82% |
| 7 | 67.69% | 67.47% | 64.76% | 57.83% | 2.93% | 9.64% |
| 8 | 64.23% | 65.06% | 59.97% | 65.06% | 4.26% | 0.00% |
| 9 | 63.70% | 68.67% | 58.78% | 57.83% | 4.92% | 10.84% |
| 10 | 57.71% | 57.83% | 57.31% | 60.24% | 0.40% | −2.41% |
| 11 | 59.18% | 60.24% | 56.38% | 67.47% | 2.79% | −7.23% |
| 12 | 59.18% | 69.88% | 56.65% | 51.81% | 2.53% | 18.07% |
| 13 | 57.31% | 61.45% | 54.79% | 53.01% | 2.53% | 8.43% |
| 14 | 55.85% | 59.04% | 53.86% | 62.65% | 1.99% | −3.61% |
| 15 | 54.12% | 54.22% | 50.66% | 57.83% | 3.46% | −3.61% |
| 16 | 53.86% | 59.04% | 52.66% | 55.42% | 1.20% | 3.61% |
| 17 | 51.33% | 39.76% | 50.00% | 60.24% | 1.33% | −20.48% |
| 18 | 54.52% | 62.65% | 51.73% | 53.01% | 2.79% | 9.64% |
| 19 | 50.00% | 56.63% | 50.00% | 38.55% | 0.00% | 18.07% |
| 20 | 47.21% | 44.58% | 47.74% | 51.81% | −0.53% | −7.23% |
aPercentages in this column were calculated by percentages in column 2 minus percentages in column 4.
bPercentages in this column were calculated by percentages in column 3 minus percentages in column 5.