Table 2. Association of clinical outcomes with gene expression and select clinical variables.
| Variables | Serum creatinine | MDRD GFR | Proteinuria | Graft loss | Death-censored graft loss |
|---|---|---|---|---|---|
| TNF-α | NS | NS | NS | Positive, p = 0.0524 | Positive, p = 0.0315 |
| CD25 | NS | NS | NS | NS | NS |
| TGF-β | NS | NS | NS | NS | NS |
| A20 | NS | NS | NS | NS | NS |
| Bcl-xl | NS | NS | NS | NS | NS |
| Bcl-2 | NS | NS | NS | Negative, p = 0.0128 | NS |
| IL-10 | NS | NS | NS | NS | NS |
| IL-6 | NS | NS | NS | NS | NS |
| PECAM | NS | Positive, p = 0.023 | NS | NS | NS |
| ICAM-1 | NS | NS | NS | NS | NS |
| Ho-1 | NS | NS | NS | NS | NS |
| CD40 | NS | NS | Negative, p = 0.0067 | NS | NS |
| CD3 | NS | Negative, p = 0.0264 | NS | NS | NS |
| IFN-γ | NS | NS | NS | NS | NS |
| NF-κB | NS | NS | NS | NS | NS |
| Recipient race | NS | NS | NS | NS | NS |
| Donor race | NS | NS | NS | NS | NS |
| Transplant number (first, second, third) | NS | NS | NS | NS | NS |
| Donor type (living or deceased) | NS | NS | NS | NS | NS |
| Recipient age | NS | NS | NS | NS | NS |
| Donor age | Positive, p = 0.0412 | Negative, p = 0.0499 | NS | NS | NS |
| Warm ischemia time | NS | NS | NS | NS | NS |
| Cold ischemia time | NS | NS | NS | NS | NS |
| HLA match | NS | NS | NS | NS | NS |
| Delayed graft function | NS | NS | NS | NS | NS |
| Acute rejection | Positive, p = 0.0279 | NS | Positive, p = 0.0074 | NS | NS |
| Induction therapy with depleting agent | NS | NS | NS | NS | NS |
| Diabetes in the recipient | NS | NS | NS | NS | NS |
| Triglyceride level | NS | NS | NS | NS | NS |
| Systolic blood pressure | NS | NS | NS | NS | NS |
| Diastolic blood pressure | NS | NS | NS | NS | NS |
| Immunosuppressive drug level | NS | NS | NS | NS | NS |
| Sirolimus use | NS | NS | NS | NS | NS |
NS, not significant.