Table 2.
Common core set of DE genes modulated by L-OHP in the tested cell lines
| Gene symbol | Gene name |
Colo 320R |
HT-29R |
||
|---|---|---|---|---|---|
| Fold regulation | p value | Fold regulation | p value | ||
|
Class A | |||||
| TMX4 |
Thioredoxin-related transmembrane protein 4 |
3.43 |
1.18E-06 |
2.73 |
6.57E-10 |
| PTPRO |
Protein tyrosine phosphatase, receptor type, O |
1.58 |
2.58E-05 |
1.85 |
1.93E-08 |
| LGALS1 |
Lectin, galactoside-binding, soluble, 12 |
2.71 |
7.32E-07 |
1.58 |
3.62E-09 |
| KRT18 |
Keratin 18, transcript variant 1 |
1.87 |
7.29E-08 |
1.54 |
1.81E-07 |
| THC2739159 |
ALU8_HUMAN (P39195) Alu subfamily SX sequence contamination warning entry, partial (8%) |
2.04 |
2.48E-04 |
1.77 |
7.46E-08 |
|
XR_019191 |
PREDICTED: Homo sapiens similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC121054), mRNA [XR_019191] |
2.00 |
7.97E-09 |
1.56 |
6.13E-08 |
|
XR_017030 |
Heat-shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) (Stress responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein) |
1.99 |
1.30E-08 |
1.53 |
8.82E-08 |
|
XR_018843 |
PREDICTED: Homo sapiens similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC649233), mRNA [XR_018843 |
1.93 |
8.66E-07 |
1.71 |
1.52E-05 |
|
AK022045 |
Homo sapiens cDNA FLJ11983 fis, clone HEMBB1001337 |
1.80 |
1.24E-05 |
1.82 |
6.51E-09 |
| THC2611661 |
RR12_SPIMX (P42344) Chloroplast 30S ribosomal protein S12, partial (11%) |
1.80 |
2.24E-04 |
1.51 |
8.50E-08 |
| THC2524582 |
Q5U0N8_HUMAN (Q5U0N8) Keratin 18 (Cell proliferation-inducing protein 46), partial (46%) [THC2524582] |
1.75 |
3.60E-07 |
1.57 |
8.96E-07 |
|
NM_173624 |
KRT18P55 keratin 18 pseudogene 55 |
1.72 |
3.34E-07 |
1.57 |
1.13E-06 |
|
XR_018670 |
PREDICTED: Homo sapiens similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC643471), mRNA [XR_018670] |
1.72 |
1.71E-07 |
1.51 |
6.88E-08 |
|
XR_015605 |
PREDICTED: similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC731794), mRNA |
1.71 |
3.34E-07 |
1.51 |
4.97E-07 |
|
BC048264 |
Homo sapiens hypothetical protein LOC283666, mRNA (cDNA clone IMAGE:4415549), partial cds |
1.71 |
3.63E-05 |
1.88 |
1.27E-08 |
|
XR_018311 |
PREDICTED: Homo sapiens similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC139060), mRNA [XR_018311] |
1.67 |
2.29E-05 |
1.55 |
1.23E-07 |
|
NM_001007139 |
Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 2, mRNA |
2.08 |
7.10E-06 |
1.53 |
6.85E-09 |
| THC2663167 |
ALU1_HUMAN (P39188) Alu subfamily J sequence contamination warning entry, partial (5%) [THC2663167] |
2.07 |
3.24E-04 |
1.55 |
1.17E-08 |
|
Class B | |||||
| IL1RAP |
Interleukin 1 receptor accessory protein |
-1.61 |
2.86E-05 |
-1.53 |
4.67E-07 |
| GRB14 |
Growth factor receptor-bound protein 14 |
-1.73 |
3.97E-07 |
-1.56 |
4.16E-09 |
| RBPMS2 |
RNA binding protein with multiple splicing 2 |
-1.60 |
1.19E-04 |
-1.58 |
8.16E-07 |
| RHOBTB1 |
Rho-related BTB domain containing 1 |
-1.58 |
7.77E-05 |
-1.67 |
3.44E-07 |
| CD302 |
CD302 molecule |
-1.88 |
2.57E-06 |
-1.68 |
1.07E-09 |
| HMGCS1 |
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 |
-1.56 |
2.38E-04 |
-1.73 |
2.77E-07 |
| POLR1D |
Polymerase (RNA) I polypeptide D, 16 kDa |
-1.52 |
1.44E-06 |
-1.74 |
3.02E-10 |
| CA12 |
Carbonic anhydrase XII (CA12), transcript variant 1 |
-2.60 |
2.55E-10 |
-1.95 |
4.95E-11 |
| AKR1B1 |
Aldo-keto reductase family 1, member B10 |
-1.91 |
1.78E-07 |
-3.18 |
2.54E-12 |
|
Class C | |||||
| IFITM3 |
Interferon induced transmembrane protein 3 |
-1.74 |
1.87E-07 |
2.08 |
1.28E-11 |
| IFITM4P |
Interferon induced transmembrane protein 4 pseudogene |
-1.60 |
3.88E-07 |
1.78 |
1.28E-08 |
| IFIH1 |
Interferon induced with helicase C domain 1 |
-2.64 |
1.40E-07 |
1.67 |
4.51E-08 |
| CFHR1 |
Complement factor H-related 1 |
-2.64 |
4.32E-09 |
1.61 |
1.70E-08 |
|
Class D | |||||
| CAMK2N1 |
Calcium/calmodulin-dependent protein kinase II inhibitor 1 |
1.64 |
1.33E-07 |
-1.55 |
3.97E-07 |
| SAMD5 |
Sterile alpha motif domain containing 5 |
1.51 |
2.41E-04 |
-1.73 |
8.09E-09 |
| NDRG1 |
N-myc downstream regulated 1 |
1.79 |
7.96E-07 |
-1.75 |
1.55E-07 |
| COL9A3 |
Collagen, type IX, alpha 3 |
1.91 |
3.92E-06 |
-1.79 |
6.45E-09 |
| IRX5 | Iroquois homeobox 5 | 1.88 | 1.94E-07 | -1.53 | 9.56E-08 |
Classes A and B represent up- respectively down-regulated genes induced by L-OHP in Colo320R and HT-29R. Classes C and D include antagonist DE genes induced by L-OHP in the tested cell lines.