Table 3.
Top canonical pathways modulated by L-OHP in Colo320R
| Canonical pathways Colo320R | p-value | Log Ratio | Molecules |
|---|---|---|---|
|
Aryl hydrocarbon receptor signaling |
1E-03 |
5.59E-02 |
HSPB3, CDKN2A, MYC, FOS, GSTM2, ALDH1A1, NQO1, TGFB2, HSPB1 |
|
HGF Signaling |
3E-03 |
6.67E-02 |
CDKN2A, MET, FOS, MAP3K6, MAP3K13, ETS2, ELK3 |
|
LPS/IL-1 mediated inhibition of RXR function |
7E-03 |
4.18E-02 |
CHST2, ABCB1, GSTM2, ALDH1A1, SLC27A2, HS3ST1, CPT1C, PLTP, HMGCS1, IL1RAP |
|
Hepatic fibrosis/hepatic stellate cell activation |
1.6E-02 |
4.79E-02 |
MET, TIMP1, ACTA2, TGFB2, IGFBP5, IL1RAP, COL3A1 |
|
Retinoate biosynthesis I |
1.8E-02 |
7.89E-02 |
ALDH1A1, RBP7, AKR1C3 |
|
Methylglyoxal degradation III |
1.68E-02 |
8.7E-02 |
AKR1C3, AKR1B1 |
|
S-methyl-5′-thioadenosine degradation II |
1.9E-02 |
1.67E-01 |
MTAP |
|
Histamine biosynthesis |
1.9E-02 |
3.33E-01 |
HDC |
|
Retinol biosynthesis |
2.5E-02 |
4.92E-02 |
DHRS3, RBP7, LPL |
|
Cell Cycle: G1/S checkpoint regulation |
2.7E-02 |
6.06E-02 |
CDKN2A, MYC, HDAC9, TGFB2 |
|
The visual cycle |
2.9E-02 |
7.14E-02 |
DHRS3, RBP7 |
|
PXR/RXR activation |
3.2E-02 |
4.6E-02 |
ABCB1, GSTM2, ALDH1A1, FOXO1 |
|
Glutamine biosynthesis I |
3.8E-02 |
1.25E-01 |
GLUL |
|
Thyroid cancer signaling |
4.2E-02 |
7.14E-02 |
PPARG, MYC, NTF3 |
| Mitochondrial L-carnitine shuttle pathway | 4.2E-02 | 9.09E-02 | SLC27A2, CPT1C |