Table 4.
Top canonical pathways modulated by L-OHP in HT-29R
| Canonical pathways HT-29R | p-value | Log ratio | Molecules |
|---|---|---|---|
|
Interferon signaling |
2,51E-05 |
1.94E-01 |
IFIT3, IFIT1, IFITM1, MX1, IRF9, PSMB8, STAT1 |
|
Methylglyoxal degradation III |
2,04E-04 |
1.74E-01 |
AKR7A3, AKR1C1/AKR1C2, AKR1B10, AKR1B1 |
|
Cholesterol biosynthesis I |
4,17E-04 |
1E-01 |
SQLE, DHCR7, MSMO1, CYP51A1 |
|
Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) |
4,17E-04 |
1E-01 |
SQLE, DHCR7, MSMO1, CYP51A1 |
|
Cholesterol biosynthesis III (via Desmosterol) |
4,17E-04 |
1E-01 |
SQLE, DHCR7, MSMO1, CYP51A1 |
|
LXR/RXR activation |
7,76E-04 |
8.09E-02 |
SCD, TTR, LDLR, SREBF1, AMBP, SERPINA1, PTGS2, TLR3, IL1RAP, CYP51A1, AGT |
|
Mevalonate pathway I |
4,47E-03 |
1.07E-01 |
IDI1, HMGCS2, HMGCS1 |
|
Creatine-phosphate biosynthesis |
4,90E-03 |
3.33E-01 |
CKB, CKMT1A/CKMT1B, LCMT2 |
|
Activation of IRF by Cytosolic pattern recognition receptors |
5,75E-03 |
8.33E-02 |
DHX58, IFIH1, IRF9, STAT1, IFIT2, ISG15 |
|
Tryptophan degradation X (Mammalian, via Tryptamine) |
1,05E-02 |
1.03E-01 |
ALDH1A3, DDC, MAOA |
|
Zymosterol biosynthesis |
1,17E-02 |
9.09E-02 |
MSMO1, CYP51A1 |
|
Maturity onset diabetes of young (MODY) signaling |
1,95E-02 |
9.68E-02 |
FOXA2, FABP1, HNF4A |
|
Eicosanoid signaling |
2,19E-02 |
6.25E-02 |
DPEP1, PNPLA3, RARRES3, PTGS2, ALOX5 |
|
Ketogenesis |
2,69E-02 |
9.52E-02 |
HMGCS2, HMGCS1 |
|
Acyl-CoA hydrolysis |
3,31E-02 |
1.25E-01 |
ACOT4, HNF4A |
|
PXR/RXR activation |
3,47E-02 |
5.75E-02 |
SCD, NR0B2, CYP2B6, HMGCS2, HNF4A |
|
Colorectal cancer metastasis signaling |
3,89E-02 |
4.67E-02 |
VEGFA, MMP7, RND3, TGFB1, FZD3, GNB5, TGFB2, PTGS2, TLR3, STAT1, FNBP1, WNT5A |
|
Aryl hydrocarbon receptor signaling |
4,17E-02 |
4.97E-02 |
TGM2, TFF1, NR0B2, ALDH1A3, TGFB1, TGFB2, ALDH18A1,NRIP1 |
|
p38 MAPK signaling |
4,27E-02 |
5.98E-02 |
DDIT3, TGFB1, TGFB2, MKNK2, RPS6KA2, STAT1, IL1RAP |
|
Choline biosynthesis III |
4.64E-02 |
9.09E-02 |
CHPT1,PLD1 |
|
Histamine degradation |
4.64E-02 |
6.9E-02 |
ALDH1A3,ABP1 |
|
Adenosine nucleotides degradation II |
4.64E-02 |
8E-02 |
NT5E, ADA |
| Wnt/β-catenin signaling | 5E-02 | 5.2E-02 | MMP7, CDH3, TGFB1, PPP2R3A, TGFBR3, FZD3, CD44, TGFB2, WNT5A |