Table 5.
Upstream regulators induced by L-OHP treatment in HT-29R
| Upstream regulator | Log ratio | Molecule type | Predicted activation state | z-score | p-value of overlap | Target molecules in dataset |
|---|---|---|---|---|---|---|
| TGM2 |
0.968 |
Enzyme |
Activated |
4.762 |
8.90E-09 |
DDX60, DDX60L, DEFA1, HIP1, IFI6, IFIT1, IFIT2, IFIT3, IFIT5, IRF9, MT2A, OAS3, OASL, PARP9, PHLDA1, PLSCR1, RARRES3, RUNX2, SAMD9L, SLFN5, STAT1, TGFB1, XAF1 |
| STAT1 |
0.855 |
Transcription regulator |
Activated |
3.592 |
1.47E-08 |
AGT, ALDH1A3,CLIC5, DPP4, HERC6, IFI27, IFI6, IFIT1, IFIT2, IFITM1, IRF9, ISG15, KCTD12, PSMB8, PSMB9, PTGS2, RUNX1, SLFN5, STAT1, TLR3, TYMP, USP18 |
| TLR3 |
0.624 |
Transmembrane receptor |
Activated |
3.392 |
5.85E-07 |
DHX58, IFI44, IFI44L, IFI6, IFIH1, IFIT1,IFIT2, IFIT3, IFNE, ISG15, MX1, MX2, OASL, PHLDA1, PLK2, PTGS2, STAT1, TLR3, USP18 |
| INSIG1 |
-2.061 |
Other |
Activated |
3.039 |
1.74E-06 |
CXCR4, CYP51A1, DHCR7, HMGCS1, HMGCS2, IDI1, LDLR, PLD1, SCD, SQLE, SREBF1, STARD4,TGFB1 |
| NFATC2 |
0.635 |
Transcription regulator |
Activated |
3.019 |
3.84E-05 |
IFIT2, ISG15, LMO4, MX1, OASL, PLD1, PLK2, PTGS2, SH3BP5, SLCO3A1, STAT1, TGFB1,T LR3 |
| IFNE |
0.861 |
Cytokine |
Activated |
2.804 |
2.07E-07 |
IFIH1, IFIT2, MX2, PTGS2, RARRES3, STAT1, TLR3, USP18 |
| PARP9 |
1.087 |
Other |
Activated |
2.433 |
1.24E-06 |
IFI44, IFIT1, IFIT2, IFIT3, ISG15, STAT1 |
| IFIH1 |
0.742 |
Enzyme |
Activated |
2.190 |
2.68E-04 |
BST2, ISG15, MX1, PHLDA1, RND3 |
| SREBF1 |
-0.624 |
Transcription regulator |
Inhibited |
-2.980 |
1.36E-07 |
CAMK1D, CYP51A1, DHCR7, HMGCS1, HNF4A, IDI1, INSIG1, LDLR, MSMO1, NR0B2, PNPLA3, PTGS2, SCD, SQLE, SREBF1, STARD4,T GFB1, VEGFA |
| USP18 | 0.941 | Peptidase | Inhibited | -2.219 | 5.62E-05 | IFI6, IFITM3, IRF9, ISG15, MX1 |