Figure 5. Effect of altered intracellular GSH on toxicity of polycations.
Intracellular GSH was depleted in Panc-28 and Panc-1 cells by 1 h preincubation with 2.5 mM DEM. Toxicity of PAA-100, PAA-0, and PEI was evaluated by incubating DEM-treated and control untreated cells with increasing concentrations of the polycations and determining IC50 values using MTS assay after 24 h incubation. (mean ± SEM, n = 4)