Table 2.

Comparison of Dosages and Cost of Inhaled Anticholinergic Agents for the Treatment Of Chronic Obstructive Pulmonary Disease

Drug	Dose	Cost (Average Wholesale Price)
Atrovent HFA (ipratropium bromide hydrofluoroalkane)	Two inhalations (17 mcg per actuation) orally four times daily	$239.09
Spiriva HandiHaler (tiotropium bromide)	Two inhalations of the powder capsule (18-mcg capsules) orally once daily	$289.09
Tudorza (aclidinium bromide)	One inhalation (400 mcg per actuation) twice daily	$261.00

Data from LexiComp.¹⁰