Table 1.
Baseline Characteristics of 1209 patients by Mitral Regurgitation Severity.
| Characteristic | None or Trace MR (n=435) |
Mild MR (n=554) |
Moderate-Severe MR (n=220) |
P Value |
|---|---|---|---|---|
| Age, median (25th, 75th), yrs. | 59 (54, 66) | 60 (54, 68) | 60 (54, 68) | 0·287 |
| Male, no. (%) | 394 (91) | 479 (86) | 188 (85) | 0·076 |
| Previous MI, no. (%) | 330 (76) | 434 (78) | 167 (76) | 0·598 |
| Hyperlipidemia, no. (%) | 278 (64) | 322 (58) | 127 (58) | 0·126 |
| Hypertension, no. (%) | 277 (64) | 331 (60) | 118 (54) | 0·046 |
| Diabetes, no. (%) | 187 (43) | 202 (37) | 87 (40) | 0·114 |
| Chronic renal disease, no. (%) | 35 (8) | 38 (7) | 21 (10) | 0·442 |
| Previous stroke, no. (%) | 34 (8) | 40 (7) | 18 (8) | 0·883 |
| Previous PCI, no. (%) | 49 (11) | 66 (12) | 41 (19) | 0·019 |
| Previous CABG, no. (%) | 11 (3) | 13 (2) | 11 (5) | 0·118 |
| Current CCS angina class, no. (%) | 0·061 | |||
| 0 | 174 (40) | 181 (33) | 84 (38) | |
| 1 | 69 (16) | 85 (15) | 33 (15) | |
| 2 | 172 (40) | 266 (48) | 87 (40) | |
| 3 | 17 (4) | 18 (3) | 13 (6) | |
| 4 | 3 (1) | 4 (1) | 3 (1) | |
| Highest NYHA class in last 3 months, no. (%) | <0.001 | |||
| I | 29 (7) | 30 (5) | 10 (5) | |
| II | 182 (42) | 191 (35) | 63 (29) | |
| III | 175 (40) | 261 (47) | 103 (47) | |
| IV | 49 (11) | 72 (13) | 44 (20) | |
| Region, no. (%) | <0·001 | |||
| Europe | 210 (48) | 344 (62) | 119 (54) | |
| US and Canada | 93 (21) | 111 (20) | 37 (17) | |
| Other | 132 (30) | 99 (18) | 64 (29) | |
| Risk at randomization* | 8 (3, 16) | 11 (5, 19) | 17 (10, 24) | <0·001 |
| CAD distribution, no. of vessels stenosed (75% criterion), no. (%) | 0·534 | |||
| ≤1 | 111 (26) | 143 (26) | 52 (24) | |
| 2 | 178 (41) | 195 (35) | 88 (40) | |
| 3 | 146 (34) | 215 (39) | 80 (36) | |
| Left main (≥ 50% stenosis), no. (%) | 7 (2) | 17 (3) | 8 (4) | 0·218 |
| Proximal LAD (≥75% stenosis), no. (%) | 318 (73) | 372 (67) | 133 (61) | 0·004 |
| Duke CAD index, median (25th, 75th), 0–100 | 65 (39, 77) | 65 (39, 77) | 59 (39, 77) | 0·474 |
| LV ejection fraction, median (25th, 75th), % | 29 (23, 35) | 27 (21, 33) | 25 (20, 32) | <0·001 |
| ESVI, median (25th, 75th), mL/m2 | 72 (57, 94) | 80 (62, 101) | 89 (65, 122) | <0·001 |
| Six-minute walk test | ||||
| Able to perform, no. (%) | 365 (85) | 488 (88) | 188 (86) | 0·260 |
| Distance walked, median (25th, 75th), m | 350 (281, 414) | 329 (250, 407) | 335 (255, 400) | 0·044 |
Abbreviations: CABG, coronary artery bypass grafting; CAD, coronary artery disease; CCS, Canadian Cardiovascular Society; ESVI, end-systolic volume index; LAD, left anterior descending; MED, medical therapy; MI, myocardial infarction; MR, mitral regurgitation; NYHA, New York Heart Association; PCI, percutaneous coronary intervention.
*
The risk at randomization was estimated based on a model previously developed using data from the Duke Cardiovascular Database Registry13)