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. 2013 Aug 20;21(9):1653–1660. doi: 10.1038/mt.2013.150

Figure 5.

Figure 5

The effect of GJ072 analogs on TGA PTC in A-T cells measured by FC-ATMs1981. AT153LA cells with a homozygous TGA mutation were exposed to RTCs for 4 days before assaying. Restored ATM kinase activity was indicated by increased fluorescence intensity measured by flow cytometry (ΔFI). (a) Activity of GJ102, GJ103, GJ104, GJ105 and GJ106. The data shown were summarized from four independent experiments; (b) Activity of GJ109, GJ111, GJ112 and GJ113, the data shown were summarized from four independent experiments. *P ≤ 0.05 compared with nontreated A-T cells. A-T, ataxia telangiectasia; RTC, read-through compounds.