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The effect of GJ072 analogs on TAA in A-T cells measured by FC-ATMs1981. AT187LA cells with homozygous TAA mutation were exposed to RTCs for 4 days before assaying. Restored ATM kinase activity was indicated by increased “ΔFI.” (a) Activity of GJ103, GJ104, GJ105, and GJ106; (b) Activity of GJ109, GJ111, GJ112, and GJ113. Data shown in (a) and (b) were derived from three independent experiments, respectively. *P ≤ 0.05 as compared with nontreated A-T cells. A-T, ataxia telangiectasia.
