Table 2.
Enrichment analysis results of differentially expressed microRNAs (both in male and female TAAs), obtained by Diana mirPath software.
| Common MicroRNAs | KEGG Pathwaysa | Number of Genesb | p Valuec | Adjusted p Valued |
|---|---|---|---|---|
|
| ||||
| Down-regulated (5) | adherens junction | 15 | 5.20E-08 | 7.12E-06 |
| transforming growth factor β signaling | 13 | 4.35E-04 | n.s. | |
| focal adhesion | 21 | 1.00E-03 | n.s. | |
|
| ||||
| Up-regulated (11) | focal adhesion | 61 | 3.31E-11 | 5.43E-09 |
| adherens junction | 26 | 1.56E-06 | 2.56E-04 | |
| regulation of actin cytoskeleton | 55 | 1.90E-06 | 3.12E-04 | |
a
Pathways with higher enrichment in genes putatively targeted by the miRNAs indicated.
b
Number of genes belonging to the pathway and putatively targeted by all the miRNAs indicated.
c
p Values calculated by input dataset enrichment analysis performed by a Pearson’s chi-squared test as indicated by Diana mir-Path algorithm [12].
d
p Values Bonferroni-corrected for multiple testing.