Table 1.
Clinical characteristics and imaging findings in the N-F group and the control group
| Variables | N-F group | Control group | p |
|---|---|---|---|
| (n = 20) | (n = 60) | ||
| Age, years | 83 (67–90) | 82 (73–85) | 0.841 |
| Male sex | 8 (40) | 30 (50) | 0.606 |
| NIHSS on admission | l8 (l3–20) | 17 (12–20) | 0.609 |
| mRS 0-2 | 15 (75) | 46 (77) | 1.000 |
| Interval from onset to IV-tPA, h | 5.6 (4.2–12.2) | 2.4 (2.0–2.7) | <0.001 |
| Initial DWI-ASPECTS | 9 (7–9) | 8 (5–9) | 0.213 |
| Initial ischemic volume on DWI, ml | 5.3 (2.6–27.3) | 8.1 (1.2–33.9) | 0.807 |
| Past history | |||
| Ischemic stroke | 0 (0) | 8 (13) | 0.191 |
| Transient ischemic attack | 2 (10) | 3 (5) | 0.594 |
| Coronary heart disease | 3 (15) | 5 (8) | 0.405 |
| Vascular risk factor | |||
| Hypertension | 18 (90) | 46 (77) | 0.333 |
| Diabetes mellitus | 6 (30) | 15 (25) | 0.770 |
| Hyperlipidemia | 7 (35) | 18 (30) | 0.782 |
| Smoking | 6 (30) | 21 (35) | 0.789 |
| Atrial fibrillation | 14 (70) | 36 (60) | 0.595 |
| Past medication | |||
| Antiplatelet therapy | 6 (30) | 15 (25) | 0.770 |
| Anticoagulation therapy | 1 (5) | 10 (17) | 0.275 |
| Systolic blood pressure, mm Hg | 151 (140–165) | 154 (138–166) | 0.770 |
| Diastolic blood pressure, mm Hg | 80 (71–101) | 82 (68–98) | 0.634 |
| Stroke etiology | |||
| Cardioembolism | 16 (80) | 38 (63) | 0.270 |
| Large-artery atherosclerosis | 1 (5) | 6 (10) | 0.673 |
| Laboratory data | |||
| White blood cell count, /l | 6,555 (5,093–7,725) | 6,135 (4,943–7,743) | 0.837 |
| Red blood cell count | 407 (375–4,456) | 408 (361–442) | 0.697 |
| Hemoglobin, mg/dl | 12.6 (11.7–13.7) | 12.4 (11.2–13.8) | 0.859 |
| Platelets | 21.0 (16.5–24.2) | 18.6 (15.4–21.5) | 0.085 |
| Total cholesterol, mg/dl | 191 (163–216) | 181 (159–209) | 0.501 |
| LDL, mg/dl | 106 (86–131) | 107 (85–134) | 0.947 |
| D-dimer, μg/ml | 2.2 (1.0–3.8) | 1.4 (0.6–2.9) | 0.139 |
| Glucose, mg/dl | 118 (103–166) | 133 (113–164) | 0.182 |
| HbAlc, % | 5.7 (5.3–6.6) | 5.6 (5.2–5.9) | 0.483 |
| CRP, mg/dl | 0.13 (0.09–0.67) | 0.12 (0.04–0.50) | 0.344 |
| BNP, pg/ml | 223.4 (80.9–440.8) | 135.6 (72.3–329.7) | 0.417 |
| Site of occlusion | |||
| ICA | 7 (35) | 21 (35) | 1.000 |
| Horizontal portion of MCA | 10 (50) | 30 (50) | 1.000 |
| Vertical portion of MCA | 3 (15) | 9 (15) | 1.000 |
Values represent median with the interquartile range in parentheses or number with the percentage in parentheses.
LDL = Low-density lipoprotein cholesterol
HbA1c = hemoglobin A1c
CRP = C-reactive protein
BNP = brain natriuretic peptide.